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BiographyCarlijn Bouten is professor of Cell-Matrix Interactions at the department Biomedical Engineering of the Eindhoven University of Technology (TU/e). She was trained in functional anatomy and biomechanics, as well as exercise physiology, at the department of Human Movement Sciences, VU Amsterdam (MSc 1991), and obtained her PhD degree in 1995 from the TU/e. She performed postdoctoral research at the Université Laval (Quebec), Queen Mary University London, and Eindhoven University of Technology. In 1998 she became assistant professor in Cellular Biomechanics in the department of Mechanical Engineering, TU/e, and in 2002 she became associate professor of Tissue Engineering in the department of Biomedical Engineering, TU/e. Her current research focuses on cell-matrix interactions for cardiovascular regeneration, with special emphasis on the mechanoregulation of growth, differentiation, adaptation and remodeling. She uses ‘living’ model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify these aspects, preferably in real-time. In 2002 she was awarded by the NWO-Aspasia program and in 2003 she received a NWO-Vici grant for her research on skeletal muscle and heart valve tissue engineering, respectively. From 2005-2010 she was member of the 'The Young Academy' of the Royal Netherlands Academy of Arts and Sciences. Education
Refereed journal publications2011D. van Geemen, P.W. Riem Vis, R.S. Soekhradj - Soechit, J.P.G. Sluijter, M. de Liefde - van Beest, J. Kluin, C.V.C. Bouten, Decreased mechanical properties of heart valve tissue constructs cultured in platelet lysate as compared to fetal bovine serum, Tissue Eng Part C: Methods, -(-), Epub, ahead of print, (2011)P.W. Riem Vis, J. Kluin, J.P.G. Sluijter, L.A. van Herwerden, C.V.C. Bouten, Environmental regulation of valvulogenesis:implications for tissue engineering, EJCTS, 39(1), 8-17, (2011) M.A.A. van Vlimmeren, A. Driessen - Mol, C.W.J. Oomens, W.J.T. Janssen - van den Broek, R. Stoop, C.V.C. Bouten, F.P.T. Baaijens, Low oxygen concentrations impair tissue development in tissue-engineered cardiovascular constructs, Tissue Eng Part A, In pr(-), -, (2011) C.V.C. Bouten, P.Y.W. Dankers, A. Driessen - Mol, S. Pedron, A.M. Brizard, F.P.T. Baaijens, Substrates for cardiovascular tissue engineering, Advanced Drug Delivery Reviews, 63(4-5), 221-241, (2011) 2010M.A.A. van Vlimmeren, A. Driessen - Mol, W.J.T. Janssen - van den Broek, C.V.C. Bouten, F.P.T. Baaijens, Controlling matrix formation and cross-linking by hypoxia in cardiovascular tissue engineering, J. Appl. Physiol., 109(-), 1483-1491, (2010)A. Driessen - Mol, C.V.C. Bouten, F.P.T. Baaijens, Instructive materials for functional tissue engineering, Macromol Biosci, 10(11), 1283-1284, (2010) F.P.T. Baaijens, C.V.C. Bouten, N.J.B. Driessen, Modeling collagen remodeling, J. Biomech., 43(1), 166-175, (2010) P.W. Riem Vis, C.V.C. Bouten, J.P.G. Sluijter, L.A. van Herwerden, J. Kluin, Platelet lysate as an autologous alternative for fetal bovine serum in cardiovascular tissue engineering, Tissue Eng Part A, 16(4), 1317-1327, (2010) M.A.J. Cox, J. Kortsmit, N.J.B. Driessen, C.V.C. Bouten, F.P.T. Baaijens, Tissue engineered heart valves develop native-like collagen fiber architecture, Tissue Eng Part A, 16(5), 1527-1537, (2010) 2009A. Balguid, A. Driessen - Mol, M.A.A. van Vlimmeren, F.P.T. Baaijens, C.V.C. Bouten, Hypoxia induces near-native mechanical properties of engineered heart valve tissue, Circulation, 119(-), 290-297, (2009)M.P. Rubbens, A. Driessen - Mol, R.A. Boerboom, R.A. Bank, F.P.T. Baaijens, C.V.C. Bouten, Intermittent straining accelerates the development of tissue properties in engineered heart valve tissue, Tissue Eng Part A, 15(5), 999-1008, (2009) F.P.T. Baaijens, C.V.C. Bouten, N.J.B. Driessen, Modeling collagen remodeling, J. Biomech., -(-), available online, 20, (2009) M.P. Rubbens, A. Driessen - Mol, R.A. Boerboom, M. Koppert, H.C. van Assen, B.M. ter Haar Romenij, F.P.T. Baaijens, C.V.C. Bouten, Quantification of the temporal evolution of collagen orientation in mechanically conditioned engineered cardiovascular tissues, Annals of Biomed.Eng., 37(7), 1263-1272, (2009) M.P. Rubbens, A. Driessen - Mol, M.H. van Marion, R. Hanemaaijer, R.A. Bank, F.P.T. Baaijens, C.V.C. Bouten, Straining-mode dependent collagen remodeling in engineered cardiovascular tissues, Tissue Eng Part A, 15(4), 841-849, (2009) A. Balguid, A. Driessen - Mol, M.H. van Marion, R.A. Bank, C.V.C. Bouten, F.P.T. Baaijens, Tailoring fiber diameter in electrospun PCL scaffolds for optimal cellular infiltration in cardiovascular tissue engineering, Tissue Eng Part A, 15(2), 437-444, (2009) A. Driessen - Mol, A.I.P.M. Smits, C.V.C. Bouten, F.P.T. Baaijens, Tissue engineering of heart valves: advances and current challenges, Expert Reviews Medical Devices, 6(3), 259-275, (2009) J. Hjortnaes, C.V.C. Bouten, L.A. van Herwerden, P.F. Grundeman, J. Kluin, Translating Autologous Heart Valve Tissue Engineering from Bench to Bed, Tissue Eng Part B: Reviews, 15(3), 307-317, (2009) 2008R.A. Boerboom, M.P. Rubbens, N.J.B. Driessen, C.V.C. Bouten, F.P.T. Baaijens, Effect of strain magnitude on the tissue properties of engineered cardiovascular structures, Annals of Biomed.Eng., 36(2), 244-253, (2008)L. Klouda, C.M. Vaz, A. Driessen - Mol, F.P.T. Baaijens, C.V.C. Bouten, Effect or biomimetic conditions on mechanical and structural integrity of PGA/P4HB and electrospun PCL scaffolds, J. of Mat. Sc.: Mat. in Med., 19, 1137-1144, (2008) F.E.M. Janssen, C.V.C. Bouten, G.M.J. van Leeuwen, A.A. van Steenhoven, Effects of temperature and doxorubicin exposure on keratinocyte damage in vitro, In Vitro Cell Dev Biol Anim, 44(3-4), 81-86, (2008) M.A.J. Cox, N.J.B. Driessen, R.A. Boerboom, C.V.C. Bouten, F.P.T. Baaijens, Mechanical characterization of anisotropic planar biological soft tissues using finite indentation: experimental feasibility, J. Biomech., 41(2), 422-429, (2008) N.J.B. Driessen, M.A.J. Cox, C.V.C. Bouten, F.P.T. Baaijens, Remodeling of the angular collagen fiber distribution in cardiovascular tissues, Biomech Mod Mechanobiol, 7, 93-103, (2008) A. Balguid, N.J.B. Driessen, A. Driessen - Mol, J.P.J. Schmitz, F. Verheyen, C.V.C. Bouten, F.P.T. Baaijens, Stress related collagen ultrastructure in human aortic valves - implications for tissue engineering, J. Biomech., 41, 2612-2617, (2008) D. Gawlitta, K.J.M. Boonen, C.W.J. Oomens, F.P.T. Baaijens, C.V.C. Bouten, The influence of serum-free culture conditions on skeletal muscle differentiation in a tissue-engineered model, Tissue Engineering, Part(1), 161-171, (2008) 2007D. Bronneberg, S.W. Spiekstra, L.H. Cornelissen, C.W.J. Oomens, S. Gibbs, F.P.T. Baaijens, C.V.C. Bouten, Cytokine and chemokine release upon prolonged mechanical loading of the epidermis, Exp. Dermatol., 16(7), 567-579, (2007)R.A. Boerboom, K. Nash-Krahn, R.T.A. Megens, M.A.M.J. van Zandvoort, M. Merkx, C.V.C. Bouten, High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe, J. Struct. Biol., 159, 392-399, (2007) N.J.B. Driessen, A. Driessen - Mol, C.V.C. Bouten, F.P.T. Baaijens, Modeling the mechanics of tissue-engineered human heart valve leaflets, J. Biomech., 40(2), 325-334, (2007) D. Gawlitta, C.W.J. Oomens, D.L. Bader, F.P.T. Baaijens, C.V.C. Bouten, Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle, J. Appl. Physiol., 103(2), 464-473, (2007) D. Gawlitta, W. Li, C.W.J. Oomens, F.P.T. Baaijens, D.L. Bader, C.V.C. Bouten, The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study, Ann. Biomed. Eng., 35(2), 273-284, (2007) A. Balguid, M.P. Rubbens, A. Driessen - Mol, R.A. Bank, A.J.J.C. Bogers, J.P. van Kats, B.A.J.M. de Mol, F.P.T. Baaijens, C.V.C. Bouten, The role of collagen cross-links in biomechanical behavior of human aortic heart valve leaflets: Relevance for tissue engineering, Tissue Engineering, 13(7), 1501-1511, (2007) 2006D. Bronneberg, C.V.C. Bouten, C.W.J. Oomens, P.M. van Kemenade, F.P.T. Baaijens, An in vitro model system to study the damaging effects of prolonged mechanical loading of the epidermis, Annals of Biomed.Eng., 34(3), 506-514, (2006)A. Driessen - Mol, M.C.M. Rutten, N.J.B. Driessen, C.V.C. Bouten, G. Zund, F.P.T. Baaijens, S. Hoerstrup, Autologous human tissue-engineered heart valves: prospects for systemic applications, Circulation, 114(sup I), I152-8, (2006) K. Nash-Krahn, C.V.C. Bouten, S. van Tuijl, M.A.M.J. van Zandvoort, M. Merkx, Fluorecently labeled collagen binding proteins allow specific visualization of collagen in tissues and live cell culture, Anal. Biochem., 350, 177-185, (2006) M.A.J. Cox, N.J.B. Driessen, C.V.C. Bouten, F.P.T. Baaijens, Mechanical characterization of anisotropic planar biological soft tissues using large indentation: A computational feasibility study, J. Biomech. Eng., 128(3), 428-436, (2006) 2005N.J.B. Driessen, C.V.C. Bouten, F.P.T. Baaijens, A structural constitutive model for collagenous cardiovascular tissues incorporating the angular fiber distribution, J. Biomech. Eng., 127(3), 494-503, (2005)Y.N. Wang, C.V.C. Bouten, D.A. Lee, D.L. Bader, Compression induced damage in a muscle cell model in vitro , J. Engineering in Medicine, 219(-), 1-12, (2005) C.M. Vaz, S. van Tuijl, C.V.C. Bouten, F.P.T. Baaijens, Design of scaffolds for blood vessel tissue engineering using a multi-layering electrospinning technique , Acta Biomaterialia, 1, 575-582, (2005) D. Gawlitta, C.W.J. Oomens, F.P.T. Baaijens, C.V.C. Bouten, Evaluation of a continuous quantification method of apoptosis and necrosis in tissue cultures, Cytotechnology, 46, 139-150, (2005) A. Driessen - Mol, M.I. van Lieshout, G.C. Dam, S.P. Hoerstrup, F.P.T. Baaijens, C.V.C. Bouten, Fibrin as a cell carrier in cardiovascular tissue engineering applications, Biomaterials, 26(-), 3113-3121, (2005) N.J.B. Driessen, C.V.C. Bouten, F.P.T. Baaijens, Improved prediction of the collagen fiber architecture in the aortic heart valve, J. Biomech. Eng., 127(2), 329-336, (2005) E.A.G. Peeters, C.W.J. Oomens, C.V.C. Bouten, D.L. Bader, F.P.T. Baaijens, Mechanical and failure properties of single attached cells under compression, J. Biomech., 38(8), 1685-1693, (2005) D.C. Popescu, R. Lems, N. Rossi, C. Yeoh, J. Loos, S.J. Holder, C.V.C. Bouten, N.A.J.M. Sommerdijk, The patterning and alignment of muscle cells using the selective adhesion of POEGMA-based ABA block copolymers, Advanced Materials, 17, 2324-2329, (2005) A. Driessen - Mol, N.J.B. Driessen, M.C.M. Rutten, S.P. Hoerstrup, C.V.C. Bouten, F.P.T. Baaijens, Tissue engineering of human heart valve leaflets: a novel bioreactor for a strain-based conditioning approach, Annals of Biomed.Eng., 33(12), 1778-1788, (2005) E.A.G. Peeters, C.W.J. Oomens, C.V.C. Bouten, D.L. Bader, F.P.T. Baaijens, Viscoelastic properties of single attached cells under compression, J. Biomech. Eng., 127(2), 237 - 243, (2005) 2004N.J.B. Driessen, W. Wilson, C.V.C. Bouten, F.P.T. Baaijens, A computational model for collagen fibre remodelling in the arterial wall, J. Theor. Biol., 226(1), 53-64, (2004)E.A.G. Peeters, C.V.C. Bouten, C.W.J. Oomens, D.L. Bader, L.H.E.H. Snoeckx, F.P.T. Baaijens, Anisotropic, three-dimensional deformation of single attached cells under compression, Ann. Biomed. Eng., 32(10), 1443-1452, (2004) J.J.W.A. van Loon, H.T.E. Folgering, C.V.C. Bouten, T.H. Smit, Centrifuges and inertial shear forces, J. Grav. Physiol., 11(1), 27-36, (2004) J.L.V. Broers, E.A.G. Peeters, C.V.C. Bouten, C.W.J. Oomens, B.B. Burke, C.L. Stewart, F.P.T. Baaijens, F.C.S. Ramaekers, Decreased mechanical stiffness in LMNA -/- cells is caused by defective nucleo-skeletal integrity, Human Molecular Genetics, 13(21), 1-14, (2004) A. Driessen - Mol, C.V.C. Bouten, F.P.T. Baaijens, G. Zund, M.I. Turina, S.P. Hoerstrup, Tissue engineering of semilunar heart valves: current status and future developments, Journal of Heart Valve Disease, 13(-), 272-280, (2004) 2003R.G.M. Breuls, C.W.J. Oomens, C.V.C. Bouten, D.L. Bader, F.P.T. Baaijens, A Theoretical Analysis of Damage Evolution in Skeletal Muscle Tissue with Reference to Pressure Ulcer, J. Biomech. Eng., 125(6), 902-909, (2003)C.W.J. Oomens, O.F.J.T. Bressers, E.M.H. Bosboom, C.V.C. Bouten, D.L. Bader, Can loaded interface characteristics influence strain distributions in muscle adjacent to bony prominences, Comp. Meth. Biomech. & Biomed. Engng., 6(3), 171-180, (2003) C.C. van Donkelaar, C.V.C. Bouten, Cells, gels and the engines of life (book review), J. Biomech., 36(1), 149-150, (2003) R.G.M. Breuls, C.V.C. Bouten, C.W.J. Oomens, D.L. Bader, F.P.T. Baaijens, Compression induced cell damage in engineered muscle tissue: an in-vitro model to study pressure ulcer aetiology, Ann. Biomed. Eng., 31(11), 1357-1365, (2003) N.J.B. Driessen, R.A. Boerboom, J.M.R.J. Huyghe, C.V.C. Bouten, F.P.T. Baaijens, Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve, J. Biomech. Eng., 125(4), 549-557, (2003) R.A. Boerboom, N.J.B. Driessen, C.V.C. Bouten, J.M.R.J. Huyghe, F.P.T. Baaijens, Finite Element Model of Mechanically Induced Collagen Fibre Synthesis and Degradation in the Aortic Valve, Ann. Biomed. Eng., 31(9), 1040-1053, (2003) C.V.C. Bouten, R.G.M. Breuls, E.A.G. Peeters, C.W.J. Oomens, F.P.T. Baaijens, In-vitro models to study compressive strain-induced muscle cell damage, Biorheology, 40(1-3), 383-388, (2003) J.J.W.A. van Loon, H.T.E. Folgering, C.V.C. Bouten, J.P. Veldhuijzen, T.H. Smit, Inertial shear forces and the use of centrifuges in gravity research. What is the proper control?, J. Biomech. Eng., 125(-), 432-436, (2003) R.G.M. Breuls, A. Driessen - Mol, R. Petterson, C.W.J. Oomens, F.P.T. Baaijens, C.V.C. Bouten, Monitoring local cell viability in engineered tissue. A fast, quantitative and non-destructive approach, Tissue Engineering, 9(2), 269-281, (2003) E.A.G. Peeters, C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens, Monitoring the biomechanical response of individual muscle cells under compression: a new compression device, Med. Biol. Engng. Comp., 41(4), 498-503, (2003) E.M.H. Bosboom, C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens, K. Nicolaij, Quantifying pressure sore related muscle damage using high-resolution MRI, J. Appl. Physiol., 95, 2235 - 2240, (2003) N.J.B. Driessen, G.W.M. Peters, J.M.R.J. Huyghe, C.V.C. Bouten, F.P.T. Baaijens, Remodelling of continuously distributed collagen fibres in soft connective tissues, J. Biomech., 36(8), 1151-1158, (2003) C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens, D.L. Bader, The aetiology of pressure sores: skin deep or muscle bound?, Arch. Phys. Med. Rehab., 84(4), 616-619, (2003) A. Driessen - Mol, C.V.C. Bouten, G. Zund, C. Guenter, J.F. Visjager, M.I. Turina, F.P.T. Baaijens, S.P. Hoerstrup, The relevance of large strains in functional tissue engineering of heart valves, Thorac. Cardiovasc. Surg., 51, 78-83, (2003) 2002L.H.V. van der Woude, C.V.C. Bouten, H.E.J. Veeger, T. Quinn, Aerobic work capacity in elite wheelchair athletes: a cross-sectional analysis, Am. J. Phys. Med. Rehab, 81, 261-271, (2002)J.J.W.A. van Loon, H.T.E. Folgering, C.V.C. Bouten, J.P. Veldhuijzen, T.H. Smit, Inertial shear forces and the impact on facilities for the international space station, J. Grav. Physiol., 9(1), 359-360, (2002) R.G.M. Breuls, B.G. Sengers, C.W.J. Oomens, C.V.C. Bouten, F.P.T. Baaijens, Predicting local cell deformations in engineered tissue constructs: A multilevel finite element approach. , J. Biomech. Eng., 124, 198 - 207, (2002) T. Delhaas, S. van Engeland, J.L.V. Broers, C.V.C. Bouten, N. Kuijpers, F. Ramaekers, L.H.E.H. Snoeckx, Quantification of cytoskeletal deformation in living cells based on hierarchical feature vector matching, Am. J. Physiol., 283(2), C639-C645, (2002) T. Delhaas, S. van Engeland, J.L.V. Broers, C.V.C. Bouten, N.H.L. Kuijpers, F. Ramaekers, L.H.E.H. Snoeckx, Quantification of cytoskeletal deformation in living cells based on hierarchical featur vector matching, Am J Physiol, 283(2), C639-C645, (2002) 2001C.V.C. Bouten, M.M. Knight, D.A. Lee, D.L. Bader, Compressive deformation and damage of muscle cell sub-populations in a model system, Ann. Biomed. Eng., 29(2), 153-163, (2001)E.M.H. Bosboom, M.K.C. Hesselink, C.W.J. Oomens, C.V.C. Bouten, M. Drost, F.P.T. Baaijens, Passive transverse mechanical properties of skeletal muscle under in-vivo compression, J. Biomech., 34(10), 1365-1368, (2001) E.M.H. Bosboom, C.V.C. Bouten, C.W.J. Oomens, H. van Straaten, F.P.T. Baaijens, H. Kuipers, Quantification and localisation of damage in rat muscles after controlled loading; a new approach to study the aetiology of pressure sores, Med. Eng. Phys., 23(3), 195-200, (2001) 1998M.C.L. Snijders, C.V.C. Bouten, A.F.P. van Putten, J.E.M.H. van Bronswijk, Quantifying the potential for independent living in COPD-patients, Stud Health Technol Inform, 48, 296-300, (1998)1997C.V.C. Bouten, K.T.M. Koekkoek, M. Verduin, L. Kodde, J.D. Janssen, A triaxial accelerometer and portable data processing unit for the assessment of daily physical activity, IEEE Trans. Biomed. Eng., 44, 136-147, (1997)C.V.C. Bouten, A.A.H.J. Sauren, M. Verduin, J.D. Janssen, Effects of placement and orientation of body-fixed accelerometers on the assessment of energy expenditure during walking, Med. Biol. Eng. Comp., 35, 50-56, (1997) K.R. Westerterp, C.V.C. Bouten, Physical activity assessment: comparison between movement registration and doubly labeled water method, Z. Ernahrungswiss, 36, 263-267, (1997) 1996C.V.C. Bouten, W. van Marken Lichtenbelt, K.R. Westerterp, Body mass index and daily physical activity in anorexia nervosa, Med. Sci. Sports Exerc., 28, 967-973, (1996)C.V.C. Bouten, W.P.H.G. Verboeket-Van de Venne, K.R. Westerterp, M. Verduin, J.D. Janssen, Daily physical activity assessment in free-living subjects: comparison between movement registration and doubly labeled water, J. Appl. Physiol., 81, 1019-1026, (1996) K. Westerterp, W.P.H.G. Verboeket-Van de Venne, C.V.C. Bouten, C. de Graaf, K.H. van het Hof, J.A. Weststrate, Energy expenditure and physical activity in subjects consuming full or reduced fat products as part of their normal diet, Br. J. Nutr., 76(6), 785-795, (1996) 1995D.L.E. Pannemans, C.V.C. Bouten, K.R. Westerterp, 24h energy expenditure during a standardized activity protocol in young and elderly men, Eur. J. Clin. Nutr., 49, 49-56, (1995)1994C.V.C. Bouten, K.R. Westerterp, M. Verduin, J.D. Janssen, Assessment of energy expenditure for physical activity using a triaxial accelerometer, Med. Sci. Sports Exerc., 26, 1516-1523, (1994)More publicationsAn extended list of publications of Carlijn Bouten can be found here. |
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