Education
Research
Publications
Laboratories
Information
dr.ir. C.W.J. Oomens (Cees)
  Eindhoven University of Technology
Mechanical Engineering
Materials Technology
PO Box 513 ,GEM-Z 4.124
5600 MB Eindhoven, The Netherlands

Tel: +31 40 247 2818
Fax:+31 40 244 7355

Email:

Biography

Cees Oomens is associate professor in Biomechanics and Continuummechanics. He studied Physics at Eindhoven University of Technology. He obtained his PhD at Twente University (1985) on a study on the mechanical behaviour of skin. Currently his research is focussed on damage and adaptation of soft biological tissues. A hierarchical approach is used ranging from studies on cultured cells, tissue engineered constructs of muscle and skin, in-vivo animal studies and human studies. Theoretical models include convective and diffusive transport processes in deforming structures and interaction with growth, synthesis and damage development. Application fields are the modelling of cardiac tissue, remodeling of heart valves and blood vessels, multi- scale modeling of cartilage, skin mechanics and skin rejuvenation. A major application field is a study on the aetiology of pressure ulcers. The goals are to develop an objective method to identify patients at risk of developing a pressure ulcer and to develop techniques for early detection of deep tissue injury. From September 2009 to September 2011 he was president of the European Pressure Ulcer Advisory Panel . He is the first author of the text book: Biomechanics: Concepts and Computation

Education

8W020Biomechanics Responsible lecturer
8W030Numerical analysis of continua I Responsible lecturer
8W100Numerical Analysis of Continua II Responsible lecturer
8W290Continuum analysis Contributing lecturer

Refereed journal publications

2011

C.C. van Donkelaar, G.E. Chao, D.L. Bader, C.W.J. Oomens, A reaction-diffusion model to predict the influence of neo-matrix on the subsequent development of tissue engineered cartilage, Comp. Meth. Biomech. & Biomed. Engng., 14(5), 425 - 432, (2011)

M.A.A. van Vlimmeren, A. Driessen - Mol, C.W.J. Oomens, F.P.T. Baaijens, An in vitro model system to quantify stress generation, compaction and retraction in engineered heart valve tissue, Tissue Eng Part C: Methods, 17(10), 983-991, (2011)

S.D. Dams, M. de Liefde - van Beest, A.M. Nuijs, C.W.J. Oomens, F.P.T. Baaijens, Heat shocks enhance procollagen type I and III expression in fibroblasts in ex-vivo human skin, Skin Res Technol, 17(2), 167 - 180, (2011)

S. Loerakker, L. Solis, D.L. Bader, F.P.T. Baaijens, VK. Mushahwar, C.W.J. Oomens, How does muscle stiffness affect the internal deformations within the soft tissue layers of the buttock under constant loading, Comp. Meth. Biomech. & Biomed. Engng., -(-), accepted, (2011)

M. Geerligs, L.C.A. van Breemen, G.W.M. Peters, P.A.J. Ackermans, F.P.T. Baaijens, C.W.J. Oomens, In vitro indentation to determine the mechanical properties of epidermis, J. Biomech., 44, 1176-1181, (2011)

S. Loerakker, C.W.J. Oomens, E. Manders, T. Schakel, D.L.. Bader, F.P.T. Baaijens, K. Nicolay, G.J. Strijkers, Ischaemia-reperfusion injury in rat skeletal muscle assessed with T2-weighted and dynamic contrast-enhanced MRI, Magn Reson Med, 66(2), 528-537, (2011)

M. Geerligs, C.W.J. Oomens, P.A.J. Ackermans, F.P.T. Baaijens, G.W.M. Peters, Linear shear response of the upper skin layers , Biorheology, 48(3,4), 229-245, (2011)

M.A.A. van Vlimmeren, A. Driessen - Mol, C.W.J. Oomens, W.J.T. Janssen - van den Broek, R. Stoop, C.V.C. Bouten, F.P.T. Baaijens, Low oxygen concentrations impair tissue development in tissue-engineered cardiovascular constructs, Tissue Eng Part A, In pr(-), -, (2011)

S. Loerakker, E. Manders, G.J. Strijkers, K. Nicolay, F.P.T. Baaijens, D.L. Bader, C.W.J. Oomens, The effects of deformation, ischaemia and reperfusion on the development of muscle damage during prolonged loading, J. Appl. Phys., 111(4), 1168-1177, (2011)

S. Loerakker, D.L. Bader, F.P.T. Baaijens, C.W.J. Oomens, Which factors influence the ability of a computational model to predict the in vivo deformation behaviour of skeletal muscle, Comp. Meth. Biomech. & Biomed. Engng., -(-), in press, (2011)

2010

B.J. van Nierop, A. Stekelenburg, S. Loerakker, C.W.J. Oomens, D.L.. Bader, G.J. Strijkers, K. Nicolay, Diffusion of water in skeletal muscle tissue is not influenced by compression in a rat model of deep tissue injury, J. Biomech., 43(3), 570 - 575, (2010)

M. Geerligs, G.W.M. Peters, P.A.J. Ackermans, C.W.J. Oomens, F.P.T. Baaijens, Does subcutaneous adipose tissue behave as an (anti-)thyxotropic material?, J. Biomech., 43(6), 1153-1159, (2010)

K.K. Ceelen, D. Gawlitta, D.L. Bader, C.W.J. Oomens, Numerical analysis of ischaemia- and compression-induced injury in tissue-engineered skeletal muscle constructs, Ann. Biomed. Eng., 38(3), 570 - 582, (2010)

S.D. Dams, M. de Liefde - van Beest, A.M. Nuijs, C.W.J. Oomens, F.P.T. Baaijens, Pulsed heat shocks enhance procollagen type I and procollagen type III expression in human dermal fibroblasts, Skin Res Technol, 16(-3), 354-364, (2010)

S. Portnoy, J. van Haare, RPJ. Geers, A. Kristal, I. Siev-Ner, HAM. Seelen, C.W.J. Oomens, A.G. Gefen, Real-Time Subject-Specific Analyses of Dynamic Internal Tissue Loads in the Residual Limb of Transtibial Amputees, Med. Eng. Phys., 32(-), 312 - 323, (2010)

S. Loerakker, A. Stekelenburg, G.J. Strijkers, J.J.M. Rijpkema, F.P.T. Baaijens, D.L. Bader, K. Nicolay, C.W.J. Oomens, Temporal effects of mechanical loading on deformation-induced damage in skeletal muscle tissue, Ann. Biomed. Eng., 38(8), 2577-2587, (2010)

C.W.J. Oomens, S. Loerakker, D.L. Bader, The importance of internal strain as opposed to interface pressure in the prevention of pressure related deep tissue injury Journal of Tissue Viability, Journal of Tissue Viability, 19(-), 35 - 42, (2010)

2009

T. Nagel, S. Loerakker, C.W.J. Oomens, A theoretical model to study the eff ects of cellular stiff ening on the damage evolution in deep tissue injury, Comp. Meth. Biomech. & Biomed. Engng., 12(5), 585 - 598, (2009)

K.K. Ceelen, C.W.J. Oomens, A. Stekelenburg, D.L. Bader, F.P.T. Baaijens, Changes in intracellular calcium during compression, Experimental Mechanics, 49(1), 25 - 33, (2009)

L.H. Cornelissen, D. Bronneberg, D.L. Bader, F.P.T. Baaijens, C.W.J. Oomens, The transport profile of cytokines in epidermal equivalents subjected to mechanical loading, Ann. Biomed. Eng., 37(5), 1007-1018, (2009)

2008

K.K. Ceelen, A. Stekelenburg, S. Loerakker, G.J. Strijkers, D.L. Bader, K. Nicolaij, F.P.T. Baaijens, C.W.J. Oomens, Compresion-induced damage and internal tissue strains are related, J. Biomech., 41(16), 3399-3404, (2008)

A. Stekelenburg, D. Gawlitta, D.L.. Bader, C.W.J. Oomens, Deep tissue injury: how deep is our understanding?, Arch. Phys. Med. Rehab., 89(-), 1410-1413, (2008)

L.H. Cornelissen, D. Bronneberg, C.W.J. Oomens, F.P.T. Baaijens, Diffusion measurements in epidermal tissues with fluorescent recovery after photobleaching, Skin Res Technol, 14(4), 462-467, (2008)

M. Geerligs, G.W.M. Peters, P.A.J. Ackermans, C.W.J. Oomens, F.P.T. Baaijens, Linear viscoelastic behavior of subcutaneous adipose tissue, Biorheology, 45(6), 677-688, (2008)

K.K. Ceelen, C.W.J. Oomens, F.P.T. Baaijens, Microstructural analysis of deformation-induced hypoxic damage in skeletal muscle, Biomech Mod Mechanobiol, 7(4), 277-284, (2008)

A.G. Gefen, B.J. van Nierop, D.L.. Bader, C.W.J. Oomens, Strain-time cell death threshold for skeletal muscle in a tissue-engineered model system for deep tissue injury, J. Biomech., 41(-), 2003-2012, (2008)

A.G. Gefen, L.H. Cornelissen, D. Gawlitta, D.L. Bader, C.W.J. Oomens, The Free Diffusion of Macromolecules in Tissue-Engineered Skeletal Muscle Subjected to Large Deformations, J. Biomech., 41(--), 845 - 853, (2008)

D. Gawlitta, K.J.M. Boonen, C.W.J. Oomens, F.P.T. Baaijens, C.V.C. Bouten, The influence of serum-free culture conditions on skeletal muscle differentiation in a tissue-engineered model, Tissue Engineering, Part(1), 161-171, (2008)

M.A.J. Cox, D. Gawlitta, N.J.B. Driessen, C.W.J. Oomens, F.P.T. Baaijens, The non-linear mechanical properties of soft engineered biological tissues determined by finite spherical indentation , Comp. Meth. Biomech. & Biomed. Engng., 11(5), 585-592, (2008)

K.K. Ceelen, A. Stekelenburg, J.L.J. Mulders, F.P.T. Baaijens, C.W.J. Oomens, Validation of a dedicated finite element model of skeletal muscle compression with MR tagging measurements, J. Biomech. Eng., 130(6), 061015 (1 - 7), (2008)

2007

D. Bronneberg, S.W. Spiekstra, L.H. Cornelissen, C.W.J. Oomens, S. Gibbs, F.P.T. Baaijens, C.V.C. Bouten, Cytokine and chemokine release upon prolonged mechanical loading of the epidermis, Exp. Dermatol., 16(7), 567-579, (2007)

L.H. Cornelissen, C.W.J. Oomens, J.M.R.J. Huyghe, F.P.T. Baaijens, Mechanisms that play a role in the maintenance of the calcium gradient in the epidermis, Skin Res Technol, 13(4), 369-376, (2007)

D. Gawlitta, C.W.J. Oomens, D.L. Bader, F.P.T. Baaijens, C.V.C. Bouten, Temporal differences in the influence of ischemic factors and deformation on the metabolism of engineered skeletal muscle, J. Appl. Physiol., 103(2), 464-473, (2007)

D. Gawlitta, W. Li, C.W.J. Oomens, F.P.T. Baaijens, D.L. Bader, C.V.C. Bouten, The relative contributions of compression and hypoxia to development of muscle tissue damage: an in vitro study, Ann. Biomed. Eng., 35(2), 273-284, (2007)

A. Stekelenburg, G.J. Strijkers, H. Parusel, D.L.. Bader, K. Nicolay, C.W.J. Oomens, The role of ischemia and deformation in the onset of compression induced, J. Appl. Physiol., 102(5), 2002-2011, (2007)

2006

A. Stekelenburg, C.W.J. Oomens, G.J. Strijkers (contact), A.H.J. de Graaf, D.L. Bader, K. Nicolay, A new MR-compatible loading device to study in-vivo muscle damage development in rats due to compressive loading , Med. Eng. Phys., 28(-), 331-338, (2006)

D. Bronneberg, C.V.C. Bouten, C.W.J. Oomens, P.M. van Kemenade, F.P.T. Baaijens, An in vitro model system to study the damaging effects of prolonged mechanical loading of the epidermis, Annals of Biomed.Eng., 34(3), 506-514, (2006)

A. Stekelenburg, C.W.J. Oomens, G.J. Strijkers (contact), K. Nicolaij, D.L. Bader, Compression-induced deep tissue injury examined with magnetic resonance imaging and histology., J. Appl. Physiol., 100(-), 1946-1954, (2006)

B.G. Sengers, C.W.J. Oomens, TQD. Nguyen, D.L. Bader, Computational Modeling to Predict the Temporal Regulation of Chondrocyte Metabolism in Response to Various Dynamic Compression Regimens, Biomech Mod Mechanobiol, 5(2-3), 111 - 122, (2006)

J.J. Prompers, J. Jeneson, M.R. Drost, C.W.J. Oomens, G.J. Strijkers, K. Nicolaij, Dynamic MRS and MRI of skeletal muscle function and biomechanics, NMR Biomed, 19, 927 - 953, (2006)

F.M. Hendriks, D. Brokken, C.W.J. Oomens, D.L. Bader, F.P.T. Baaijens, The relative contributions of different skin layers to the mechanical behaviour of human skin in vivo using suction experiments, Med. Eng. Phys., 28(3), 259-266, (2006)

2005

B.G. Sengers, C.C. van Donkelaar, C.W.J. Oomens, F.P.T. Baaijens, A computational study of culture conditions and nutrient supply in cartilage tissue engineering, Biotechnology Progress, 21(-), 1252-1261, (2005)

R.A. Baldewsing, J.A. Schaar, F. Mastik, C.W.J. Oomens, A.FW. van der Steen, Assessment of vulnerable plaque composition by matching the deformation of a parametric plaque model to measured plaque deformation, IEEE Trans Med Imag, 24(4), 514 - 528, (2005)

M. Drost, R.P. Hesselink, C.W.J. Oomens, G. van der Vusse, Effects of non-contractile inclusions on mechanical performance of skeletal muscle, J. Biomech., 38, 1035-1043, (2005)

D. Gawlitta, C.W.J. Oomens, F.P.T. Baaijens, C.V.C. Bouten, Evaluation of a continuous quantification method of apoptosis and necrosis in tissue cultures, Cytotechnology, 46, 139-150, (2005)

E.A.G. Peeters, C.W.J. Oomens, C.V.C. Bouten, D.L. Bader, F.P.T. Baaijens, Mechanical and failure properties of single attached cells under compression, J. Biomech., 38(8), 1685-1693, (2005)

B.G. Sengers, H.K. Heywood, D.A. Lee, C.W.J. Oomens, D.L. Bader, Nutrient utilization by bovine articular chondrocytes: a combined experimental and theoretical approach, J. Biomech. Eng., 127(-), 758 - 766, (2005)

M.C. van Turnhout, G.W.M. Peters, A. Stekelenburg, C.W.J. Oomens, Passive transverse mechanical properties as a function of temperature of rat skeletal muscle in vitro, Biorheology, 42(3), 193-207, (2005)

E.A.G. Peeters, C.W.J. Oomens, C.V.C. Bouten, D.L. Bader, F.P.T. Baaijens, Viscoelastic properties of single attached cells under compression, J. Biomech. Eng., 127(2), 237 - 243, (2005)

2004

M.M. Verver, J. van Hoof, C.W.J. Oomens, J.S.H.M. Wismans, F.P.T. Baaijens, A finite element model of the human buttocks for prediction , Comp. Meth. Biomech. & Biomed. Engng., 7(4), 193-203, (2004)

B.G. Sengers, C.W.J. Oomens, F.P.T. Baaijens, An integrated finite element approach to mechanics, transport and biosynthesis in tissue engineering, J. Biomech. Eng., 126, 82-91, (2004)

E.A.G. Peeters, C.V.C. Bouten, C.W.J. Oomens, D.L. Bader, L.H.E.H. Snoeckx, F.P.T. Baaijens, Anisotropic, three-dimensional deformation of single attached cells under compression, Ann. Biomed. Eng., 32(10), 1443-1452, (2004)

J.L.V. Broers, E.A.G. Peeters, C.V.C. Bouten, C.W.J. Oomens, B.B. Burke, C.L. Stewart, F.P.T. Baaijens, F.C.S. Ramaekers, Decreased mechanical stiffness in LMNA -/- cells is caused by defective nucleo-skeletal integrity, Human Molecular Genetics, 13(21), 1-14, (2004)

F.M. Hendriks, D. Brokken, C.W.J. Oomens, F.P.T. Baaijens, Influence of hydration and experimental length scale on themechanical response of human skin in vivo, using optical coherence tomography, Skin Res Technol, 10(4), 231-241, (2004)

B.G. Sengers, C.C. van Donkelaar, C.W.J. Oomens, F.P.T. Baaijens, The local matrix distribution and the functional development of tissue engineered cartilage, a finite element study, Ann. Biomed. Eng., 32(12), 1718-1727, (2004)

2003

F.M. Hendriks, D. Brokken, J. van Eemeren, C.W.J. Oomens, F.P.T. Baaijens, J.B.A.M. Horsten, A numerical-experimental method to characterize the non-linear mechanical behaviour of human skin, Skin Res Technol, 9(-), 274-283, (2003)

R.G.M. Breuls, C.W.J. Oomens, C.V.C. Bouten, D.L. Bader, F.P.T. Baaijens, A Theoretical Analysis of Damage Evolution in Skeletal Muscle Tissue with Reference to Pressure Ulcer, J. Biomech. Eng., 125(6), 902-909, (2003)

C.W.J. Oomens, O.F.J.T. Bressers, E.M.H. Bosboom, C.V.C. Bouten, D.L. Bader, Can loaded interface characteristics influence strain distributions in muscle adjacent to bony prominences, Comp. Meth. Biomech. & Biomed. Engng., 6(3), 171-180, (2003)

R.G.M. Breuls, C.V.C. Bouten, C.W.J. Oomens, D.L. Bader, F.P.T. Baaijens, Compression induced cell damage in engineered muscle tissue: an in-vitro model to study pressure ulcer aetiology, Ann. Biomed. Eng., 31(11), 1357-1365, (2003)

M.M. Verver, J. van Hoof, C.W.J. Oomens, N. van de Wouw, J.S.H.M. Wismans, Estimation of spinal loading in vertical vibrations by numerical simulations, Clin. Biomech., 18(9), 800-811, (2003)

C.W.J. Oomens, M. Maenhout, C.H.G.A. van Oijen, M. Drost, F.P.T. Baaijens, Finite element modelling of contracting skeletal muscle, Phil Trans R Soc Lon B, 358(1437), 1453-1460, (2003)

C.V.C. Bouten, R.G.M. Breuls, E.A.G. Peeters, C.W.J. Oomens, F.P.T. Baaijens, In-vitro models to study compressive strain-induced muscle cell damage, Biorheology, 40(1-3), 383-388, (2003)

R.G.M. Breuls, A. Driessen - Mol, R. Petterson, C.W.J. Oomens, F.P.T. Baaijens, C.V.C. Bouten, Monitoring local cell viability in engineered tissue. A fast, quantitative and non-destructive approach, Tissue Engineering, 9(2), 269-281, (2003)

E.A.G. Peeters, C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens, Monitoring the biomechanical response of individual muscle cells under compression: a new compression device, Med. Biol. Engng. Comp., 41(4), 498-503, (2003)

E.M.H. Bosboom, C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens, K. Nicolaij, Quantifying pressure sore related muscle damage using high-resolution MRI, J. Appl. Physiol., 95, 2235 - 2240, (2003)

M. Drost, M. Maenhout, P.J.B. Willems, C.W.J. Oomens, F.P.T. Baaijens, M.K.C. Hesselink, Spatial and temporal heterogeneity of superficial muscle strain during in situ fixed-end contractions, J. Biomech., 36(7), 1055-1063, (2003)

C.V.C. Bouten, C.W.J. Oomens, F.P.T. Baaijens, D.L. Bader, The aetiology of pressure sores: skin deep or muscle bound?, Arch. Phys. Med. Rehab., 84(4), 616-619, (2003)

2002

R.G.M. Breuls, B.G. Sengers, C.W.J. Oomens, C.V.C. Bouten, F.P.T. Baaijens, Predicting local cell deformations in engineered tissue constructs: A multilevel finite element approach. , J. Biomech. Eng., 124, 198 - 207, (2002)

2001

E.M.H. Bosboom, M.K.C. Hesselink, C.W.J. Oomens, C.V.C. Bouten, M. Drost, F.P.T. Baaijens, Passive transverse mechanical properties of skeletal muscle under in-vivo compression, J. Biomech., 34(10), 1365-1368, (2001)

E.M.H. Bosboom, C.V.C. Bouten, C.W.J. Oomens, H. van Straaten, F.P.T. Baaijens, H. Kuipers, Quantification and localisation of damage in rat muscles after controlled loading; a new approach to study the aetiology of pressure sores, Med. Eng. Phys., 23(3), 195-200, (2001)

M.E. Roersma, L.F.A. Douven, K. Lefki, C.W.J. Oomens, The failure behavior of the anchorage of hairs during slow extraction, J. Biomech., 34(3), 319 - 325, (2001)

2000

A.W.J. Gielen, C.W.J. Oomens, P.H.M. Bovendeerd, T. Arts, J.D. Janssen, A Finite Element Approach for Skeletal Muscle using a Distributed Moment Model of Contraction., Comp. Meth. Biomech. & Biomed. Engng., 3, 231-244, (2000)

1999

O.M.G.C. Op den Camp, C.W.J. Oomens, F.E. Veldpaus, J.D. Janssen, An Efficient Algorithm to Estimate Material Parameters of Biphasic Mixtures, Int. J. Numer. Meth. Engng, 45, 1315 - 1331, (1999)

R. Meijer, L.F.A. Douven, C.W.J. Oomens, Characterisation of Anisotropic and Non-linear Behaviour in Human Skin in-vivo, Comp. Meth. Biomech. & Biomed. Engng., 1, 13 - 27, (1999)

1998

M.H.H. Meuwissen, C.W.J. Oomens, F.P.T. Baaijens, R. Petterson, J.D. Janssen, Determination of Elasto-plastic Properties of Aluminium using a Mixed Numerical-Experimental Method, J. Mat. Proc. Techn., 75(1-3), 204-211, (1998)

1996

C.W.J. Oomens, H.J. De Heus, J.M.R.J. Huyghe, J.G.L. Nelissen, J.D. Janssen, Validation of Triphasic Mixture Theory for a Mimic of Intervertebral Disk Tissue, Biomimetics, 3(4), 171-185, (1996)

1993

C.W.J. Oomens, M.A.N. Hendriks, M.R. van Ratingen, J.D. Janssen, J.J. Kok, A Numerical - Experimental method for a mechanical characterization of biological materials, J. Biomech., 26(4/5), 617 - 621, (1993)

1990

M.H.J.W. Paas, C.W.J. Oomens, P.J.G. Schreurs, J.D. Janssen, The Mechanical Behaviour of Continuous Media with stochastic damage, Engng. Fracture Mech., 36(2), 255 -266, (1990)

1989

J.M.R.J. Huyghe, C.W.J. Oomens, D.H. van Campen, R.M. Heethaar, Low Reynolds number steady state flow through a branching network of rigid vessels: I. a mixture theory, Biorheology, 26, 55 - 71, (1989)

J.M.R.J. Huyghe, C.W.J. Oomens, D.H. van Campen, R.M. Heethaar, Low Reynolds number steady state flow through a branching network of rigid vessels: II. A finite element mixture model, Biorheology, 26, 73 - 84, (1989)

1987

C.W.J. Oomens, D.H. van Campen, H.J. Grootenboer, A mixture approach to the mechanics of skin, J. Biomech., 20, 877 - 885, (1987)

C.W.J. Oomens, D.H. van Campen, H.J. Grootenboer, In-viro compression of a soft tissue layer on a rigid foundation, J. Biomech., 20, 923 - 935, (1987)

D.G. Roddeman, C.W.J. Oomens, J.D. Janssen, J. Drukker, The wrinkling of thin membranes - part 1: Theory, J. Appl. Mech., 54, 884 - 887, (1987)

D.G. Roddeman, C.W.J. Oomens, J.D. Janssen, J. Drukker, The wrinkling of thin membranes part 2: numerical analysis., J. Appl. Mech., 54, 888 - 892, (1987)

More publications

An extended list of publications of Cees Oomens can be found here.