Education
Research
Publications
Laboratories
Information
prof.dr. K. Ito (Keita)
  Eindhoven University of Technology
Biomedical Engineering
Materials Technology
PO Box 513 ,GEM-Z 4.114
5600 MB Eindhoven, The Netherlands

Tel: +31 40 247 3851
Fax:+31 40 247 3744

Email:

Education

8W280Tissue mechanics Responsible lecturer
8W330Immunology and Infection Responsible lecturer
8Z034BMT Science class: Prof. Ito Responsible lecturer
8W130Tissue engineering Contributing lecturer

Refereed journal publications

2012

P.R. van den Broek, J.M.R.J. Huyghe, K. Ito, Biomechanical behaviour of a biomimetic artificial disc, Spine, 37(6), 1-7, (2012)

L.G.E. Cox, C.C. van Donkelaar, B. van Rietbergen, P. Emans, K. Ito, Decreased bone tissue mineralization can partly explain subchondral sclerosis observed in osteoarthritis , Bone, 50, 1152-1161, (2012)

L. Mulder, B. van Rietbergen, N. Noordhoek, K. Ito, Determination of vertebral and femoral trabecular morphology and stiffness using a flat-panel C-arm-based CT approach, Bone, 50, 200-208, (2012)

M. Khoshgoftar, W. Wilson, K. Ito, C.C. van Donkelaar, The effect of tissue-engineered cartilage biomechanical and biochemical properties on its post-implantation mechanical behavior, Biomech Mod Mechanobiol, acc, -, (2012)

L.M. Kock, C.C. van Donkelaar, K. Ito, Tissue engineering of functional articular cartilage - the current status, Cell Tissue Res, 347(3), 613-627, (2012)

2011

R.F.M. van Oers, B. van Rietbergen, K. Ito, H.W.J. Huiskes, P.A.J. Hilbers, A sclerostin-based theory for strain-induced bone formation, Biomech Mod Mechanobiol, 10(5), 663-670, (2011)

L.G.E. Cox, B. van Rietbergen, C.C. van Donkelaar, K. Ito, Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties, Biomech Mod Mechanobiol, 10(5), 701-712, (2011)

P. Christen, B. van Rietbergen, F.M. Lambers, R. Müller, K. Ito, Bone morphology allows estimation of loading history in a murine model of bone adaptation, Biomech Mod Mechanobiol, xx(x), xx, (2011)

L.G.E. Cox, B. van Rietbergen, C.C. van Donkelaar, K. Ito, Bone structural changes in osteoarthritis as a result of mechanoregulated bone adaptation: a modeling approach, OA & Cart, 19(6), 676-682, (2011)

B.G.M. van Dijk, E. Potier, K. Ito, Culturing bovine nucleus pulposus explants by balancing medium osmolarity, Tissue Eng Part C: Methods, 17(11), 1089-1096, (2011)

P.R. van den Broek, J.M.R.J. Huyghe, W. Wilson, K. Ito, Design of next generation total disk replacement, J. Biomech., , , (2011)

J. Foolen, C.C. van Donkelaar, K. Ito, Intracellular tension in periosteum/perichondrium cells regulates long bone growth, J. of Orthop. Res., 29(1), 84-91, (2011)

M. Khoshgoftar, C.C. van Donkelaar, K. Ito, Mechanical stimulation to stimulate formation of a physiological collagen architecture in tissue-engineered cartilage; a numerical study, Comp. Meth. Biomech. & Biomed. Engng., 14(2), 135-144, (2011)

R.F.M. van Oers, B. van Rietbergen, K. Ito, H.W.J. Huiskes, P.A.J. Hilbers, Simulations of trabecular remodeling and fatigue: Is remodeling helpful or harmful? , Bone, 48(5), 1210-5, (2011)

L.G.E. Cox, M.W. Lagemaat, C.C. van Donkelaar, B. van Rietbergen, M.L. Reilingh, L. Blankevoort, C.N. van Dijk, K. Ito, The role of pressurized fluid in subchondral bone cyst growth, Bone, 49(4), 762-768, (2011)

L.G.E. Cox, B. van Rietbergen, C.C. van Donkelaar, K. Ito, The turnover of mineralized growth plate cartilage into bone may be regulated by osteocytes, J. Biomech., 44(9), 1765-1770, (2011)

2010

Y. Schröder, J.M.R.J. Huyghe, C.C. van Donkelaar, K. Ito, A biochemical/biophysical 3D FE intervertebral disc model, Biomech Mod Mechanobiol, 9(5), 641-650, (2010)

S.C.. Chan, B. Gantenbein-Ritter, V.Y.. Leung, D. Chan, K.M. Cheung, K. Ito, Cryopreserved intervertebral disc with injected bone marrow-derived stromal cells: a feasibility study using organ culture, Spine, .(.), in press, (2010)

E. Potier, J. Noailly, K. Ito, Directing mesenchymal stromal cell function with mechanics, J. Biomech., .(.), in press, (2010)

J.E.M. Brouwers, B. van Rietbergen, K. Ito, H.W.J. Huiskes, Effects of vibration treatment on tibial bone of ovariectomized rats analyzed by in vivo micro-CT, J. of Orthop. Res., 28(1), 62-69, (2010)

J. Foolen, C.C. van Donkelaar, R.S. Soekhradj - Soechit, K. Ito, European Society of Biomechanics SM Perren Award 2010: An adaptation mechanism for fibrous tissue to sustained shortening, J. Biomech., 43, 3168-3176, (2010)

M.. Egermann, P..H. Heil, A. Tami, P.. Janicki, W..H. Hofstetter, P.J. Richards, K. Ito, Influence of defective bone marrow osteogenesis on fracture repair in an experimental model of senile osteoporosis, J. of Orthop. Res., 28(6), 798-804, (2010)

E. Potier, J. Noailly, C. Sprecher, K. Ito, Influencing biophysical properties of fibrin with buffer solutions, J. Mat. Sci., .(.), in press, (2010)

S. Jünger, B. Gantenbein-Ritter, S. Grad, P. Lezuo, S.J. Ferguson, M. Alini, K. Ito, The combined effects of limited nutrition and high-frequency loading on intervertebral discs with endplates, Spine, .(.), in press, (2010)

L.M. Kock, A. Ravetto, C.C. van Donkelaar, J. Foolen, P. Emans, K. Ito, Tuning the differentiation of periosteum-derived cartilage using biochemical and mechanical stimulation, Osteoarthritis Cart., 18(11), 1528-1535, (2010)

2009

J.E.M. Brouwers, F.M. Lambers, B. van Rietbergen, K. Ito, H.W.J. Huiskes, Comparison of bone loss induced by ovariectomy and neurectomy in rats analyzed by in vivo micro-CT, J. of Orthop. Res., 27(11), 1521-1527, (2009)

S. Jünger, B. Gantenbein-Ritter, P. Lezuo, M. Alini, S.J. Ferguson, K. Ito, Effect of limited nutrition on in situ intervertebral disc cells under simulated-physiological loading, Spine, 34(12), 1264-1271, (2009)

S. Zeiter, P. Lezuo, K. Ito, Effect of TGF â1, BMP-2 and hydraulic pressure on chondrogenic differentiation of bovine bone marrow mesenchymal stromal cells, Biorheology, 46(1), 455-55, (2009)

J.E.M. Brouwers, B. van Rietbergen, H.W.J. Huiskes, K. Ito, Effects of PTH treatment on tibial bone of ovariectomized rats assessed by in vivo micro-CT, Osteoporosis Int., 20(11), 1823-1835, (2009)

M.M. Pucher, A. Tami, P.M. Montavon, K. Ito, Effects of vibration treatment on tibial bone of ovariectomized rats analyzed by in vivo micro-CT, Labortatory Animals, 43(3), 266-271, (2009)

I. Gröngröft, P..H. Heil, R. Matthys, P. Lezuo, A. Tami, S.M. Perren, P.M. Montavon, K. Ito, Fixation compliance in a mouse osteotomy model induces two different processes of bone healing but does not lead to delayed union, J. Biomech., 42(13), 2089-2096, (2009)

A. Tami, M.M. Leitner, M.G. Baucke, T.L. Mueller, G.H. van Lenthe, R. Müller, K. Ito, Hydroxyapatite particles maintain peri-implant bone mantle during osseointegration in osteoporotic bone, Bone, 45(6), 1117-1127, (2009)

M.. Egermann, P..H. Heil, A. Tami, P.. Janicki, W..H. Hofstetter, P.J. Richards, K. Ito, Influence of defective bone marrow osteogenesis on fracture repair in an experimental model of senile osteoporosis, J. of Orthop. Res., .(.), in press, (2009)

E. Potier, J. Noailly, C. Sprecher, K. Ito, Influencing biophysical properties of fibrin with buffer solutions, Biomaterials, .(.), ., (2009)

M.M. Leitner, A. Tami, P.M. Montavon, K. Ito, Longitudinal as well as age-matched assessments of bone changes in the mature ovariectomized rat model, Labortatory Animals, 43(3), 266-271, (2009)

H. Isaksson, I. Gröngröft, W. Wilson, C.C. van Donkelaar, B. van Rietbergen, A. Tami, H.W.J. Huiskes, K. Ito, Remodeling of fracture callus in mice is consistent with mechanical loading and bone remodeling theory, J. of Orthop. Res., 27(5), 664-672, (2009)

J. Foolen, C.C. van Donkelaar, P. Murphy, H.W.J. Huiskes, K. Ito, Residual periosteum tension is insufficient to directly modulate bone growth, J. Biomech., 42, 152-157, (2009)

L.M. Kock, R.M. Schulz, C.C. van Donkelaar, C. Thümmler, A. Bader, K. Ito, RGD-dependent integrins are mechanotransducers in dynamically compressed tissue-engineered cartilage constructs, J. Biomech., 42, 2177–2182, (2009)

H. Isaksson, C.C. van Donkelaar, K. Ito, Sensitivity of tissue differentiation and bone healing predictions to tissue properties, J. Biomech., 42, 555-564, (2009)

S. Zeiter, M.J. van der Werf, K. Ito, The fate of bovine bone marrow stromal cells in hydrogels: a comparison to nucleus pulposus cells and articular chondrocytes, J Tiss Eng Regen Med, 3(4), 310-320, (2009)

2008

H. Isaksson, C.C. van Donkelaar, H.W.J. Huiskes, K. Ito, A mechano-regulatory bone-healing model incorporating cell-phenotype specific activity, J. Theor. Biol., 252(2), 230-246, (2008)

J. Noailly, H. van Oosterwijk, W. Wilson, T. Quinn, K. Ito, A poroviscoelastic description of fibrin gels, J. Biomech., 41(15), 3265-3269, (2008)

B. Gantenbein-Ritter, E. Potier, S. Zeiter, M.J. van der Werf, C. Sprecher, K. Ito, Accuracy of Three Techniques to Determine Cell Viability in 3D Tissues or Scaffolds., Tissue Eng Part C: Methods, 14(4), 353-8, (2008)

B. Gantenbein-Ritter, T. Grunhagen, C.R. Lee, C.C. van Donkelaar, M. Alini, K. Ito, An in vitro organ culturing system for intervertebral disc explants with vertebral endplates: a feasibility study with ovine caudal discs, Spine, 31, 2665-2673, (2008)

M. Alini, S.M.. Eisenstein, K. Ito, C. Little, A.A. Kettler, K. Masuda, J. Melrose, J. Ralphs, I. Stokes, H.J. Wilke, Are animal models useful for studying human disc disorders / degeneration?, European Spine Journal, 17, 2-19, (2008)

J. Foolen, C.C. van Donkelaar, P. Murphy, N. Nowlan, H.W.J. Huiskes, K. Ito, Collagen orientation in periosteum and perichondrium is aligned with preferential directions of tissue growth, J. of Orthop. Res., 26(9), 1263-1268, (2008)

H. Isaksson, C.C. van Donkelaar, H.W.J. Huiskes, K. Ito, Corrigendum to "A mechano-regulatory bone-healing model incorporating cell-phenotype specific activity", J. Theor. Biol., 254, 717, (2008)

H. Isaksson, C.C. van Donkelaar, H.W.J. Huiskes, J. Yao, K. Ito, Determining the most important cellular characteristics for fracture healing, using design of experiments methods, J. Theor. Biol., 255, 26-39, (2008)

B. Linke, C. Ansari Moein, O. Bösl, M.H.J. Verhofstad, C. van der Werken, K. Schwieger, K. Ito, Lateral insertion points in antegrade femoral nailing and their influence on femoral bone strains, J. of Orthop. Trauma, 22(.), 716-722, (2008)

2007

A. Ganser, R.E. Thompson, I. Tami, D. Neuhoff, A. Steiner, K. Ito, An in vivo experimental comparison of stainless steel and titanium Schanz screws for external fixation, J. of Orthop. Trauma, 33, 59-68, (2007)

H. Isaksson, O. Comas, C.C. van Donkelaar, J. Mediavilla, W. Wilson, H.W.J. Huiskes, K. Ito, Bone regeneration during distraction osteogenesis: mechano-regulation by shear strain and fluid velocity, J. Biomech., 40, 2002-2011, (2007)

G. Huber, MM. Morlock, K. Ito, Consistent hydration of intervertebral discs during in vitro testing, Med. Eng. Phys., 29(7), 808-813, (2007)

M.J. van der Werf, P. Lezuo, O. Maissen, C.C. van Donkelaar, K. Ito, Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport, J. Anat., 211, 769-774, (2007)

2006

B. Gantenbein-Ritter, T. Grunhagen, C.R. Lee, C.C. van Donkelaar, M. Alini, K. Ito, An in vitro organ culturing system for intervertebral disc explants with vertebral endplates: a feasibility study with ovine caudal discs, Spine, 31(23), 2665-2673, (2006)

H. Isaksson, W. Wilson, C.C. van Donkelaar, H.W.J. Huiskes, K. Ito, Comparison of biophysical stimuli for mechano-regulation of tissue differentiation during fracture healing, J. Biomech., 39(8), 1507-1516, (2006)

H. Isaksson, C.C. van Donkelaar, H.W.J. Huiskes, K. Ito, Corroboration of mechano-regulatory algorithms for tissue differentiation during fracture healing: comparison with in vivo results, J. of Orthop. Res., 24(5), 898-907, (2006)

W. Wilson, N.J.B. Driessen, C.C. van Donkelaar, K. Ito, Prediction of collagen orientation in articular cartilage by a collagen remodeling algorithm, OA & Cart, 14(11), 1196-1202, (2006)

N.E..B. Bishop, M..R. van Rhijn, A. Tami, R..C. Corvelijn, E..S. Schneider, K. Ito, Shear does not necessarily inhibit bone healing, Clin. Orthop. Rel. Res., 443, 307-314, (2006)

2005

W. Wilson, C.C. van Donkelaar, B. van Rietbergen, K. Ito, H.W.J. Huiskes, Erratum to ‘‘Stresses in the local collagen network of articular cartilage: a poroviscoelastic fibril-reinforced finite element study” [Journal of Biomechanics 37 (2004) 357-366] and “A fibril-reinforced poroviscoelastic swelling model for articular carti, J. Biomech., 38, 2138-2140, (2005)

S. Zeiter, N.E..B. Bishop, K. Ito, Strain modulated tissue differentiation in nuclectomized intervertebral discs, European Spine Journal, 14, 874-879, (2005)

D. Neuhoff, D.J. Thompson, V.M. Frauchiger, A. Ganser, A. Steiner, K. Ito, Strain modulated tissue differentiation in nuclectomized intervertebral discs, J. of Orthop. Trauma, 19, 543-550, (2005)

2000

D.C. Ayotte, K. Ito, S.M. Perren, S. Tepic, Direction-dependent constriction flow in a poroelastic solid: the intervertebral disc valve., J. Biomech. Eng., 122, 587-593, (2000)

M.J. Kääb, K. Ito, B. Rahn, J.M. Clark, H.P. Nötzli , Effect of mechanical load on articular cartilage collagen structure: A scanning electron-microscopic study. , Cells Tissues Organs, 167, 106-120, (2000)

C. Rahm, K. Ito, J. Auer, Lag screw fixation of equine cannon bone fractures: a biomechanical comparative study of shaft and shaftless cortex screws. , Vet Surg., 29, 564-571, (2000)

V. Beilin, G.N. Pande, K. Ito, Numerical simulation of the influence of rough bone-callus interface on the healing of fractured bone., Mech. of Comp. Mat., 36, 373-378, (2000)

S.J. Ferguson, J.T. Bryant, R. Ganz, K. Ito, The acetabular labrum seal: a poroelastic finite element model. , Clin. Biomech., 15, 463-468, (2000)

M.J. Kääb, K. Ito, J.M. Clark, H.P. Nötzli , The acute structural changes of loaded articular cartilage following meniscectomy or ACL-transection. , OA & Cart, 8(6), 464-473, (2000)

S.J. Ferguson, J.T. Bryant, R. Ganz, K. Ito, The influence of the acetabular labrum on hip joint cartilage consolidation: a poroelastic finite element model. , J. Biomech., 33, 953-960, (2000)

1999

G.R.. Owen, M.J. Kääb, K. Ito, Scanning electron microscopy of collagen network morphology at the cartilage, labrum, and bone interfaces in the acetabulum. , Scanning Microsc, 18, 83-91, (1999)

S.J. Ferguson, J.T. Bryant, K. Ito, Three dimensional computational reconstruction of mixed anatomical tissues following histological preparation. , Med. Eng. Phys., 21, 111-117, (1999)

1998

M.J. Kääb, K. Ito, J.M. Clark, H.P. Nötzli , Deformation of articular cartilage collagen structure under static and cyclic loading. , J. of Orthop. Res., 16(6), 743-751, (1998)

K. Ito, M. Grass, H. Zwipp, Internal fixation of supracondylar femoral fractures: Comparative biomechanical performance of the 95-degree blade plate and two retrograde nails. , J. of Orthop. Trauma, 12(4), 259-266, (1998)

1997

M. Leunig, S. Werlen, A. Ungersböck, K. Ito, R. Ganz, MR orthography of the hip-joint for preoperative evaluation of acetabular limbus pathology., J. Bone Joint Surg., 79B, 230-234, (1997)

1991

A. Page, M. Jasty, C. Bragdon, K. Ito, W.H. Harris, Alterations in femoral and acetabular bone strains immediately following cementless total hip arthroplasty: an in vitro canine study. , J. of Orthop. Res., 9, 738-748, (1991)

More publications

An extended list of publications of Keita Ito can be found here.